Advanced Science
Adipocyte-derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Jiarui Liu, Bingwei Wang, Zhijie Su, et al., Ruimao Zheng*
DOI: 10.1002/advs.202516081 ↗研究成果Publications
发现，记录，分享Discover, document, share
代表性成果涵盖代谢调控、脂肪稳态、神经退行性疾病、药效预测与天然化合物研究。Selected work spans metabolic regulation, adipose homeostasis, neurodegeneration, drug-response prediction and natural compounds.
代表性论文Selected publications
Advanced Science
The DMH GABA neurons play a crucial role in the regulation of cold-induced white adipose browning through DMH to LPO projection
Zhijie Su, Yujia Hou, Bingwei Wang, et al., Ruimao Zheng*
DOI: 10.1002/advs.202508513 ↗Pharmacological Research
The role of hypothalamus in the pathophysiological process of MASLD and advances in drug discovery
Shizhang Wei, Yuan Dong, Yanping Wang, et al., Ruimao Zheng*
DOI: 10.1016/j.phrs.2025.107972 ↗Research
The discovery of phages in the Substantia Nigra and its implication for Parkinson’s Disease
Yun Zhao, Changxian Xiong, Bingwei Wang, et al., Ruimao Zheng*
DOI: 10.34133/research.0657 ↗Theranostics 14(13):5316–5335
βAR-mTOR-lipin1 pathway mediates PKA-RIIβ deficiency-induced adipose browning
Bingwei Wang, Zhiping Hu, Long Cui, et al., Ruimao Zheng*
DOI: 10.7150/thno.97046 ↗Advanced Science 10(5):e2205173
RIIβ-PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning
Wang B, Zhao M, Su Z, et al., Zheng R*
DOI: 10.1002/advs.202205173 ↗Nature 610(7932):562–568
Gut bacteria alleviate smoking-related NASH by degrading gut nicotine
Chen B, Sun L, Zeng G, et al., Zheng R, et al.
Nature Biotechnology
Prediction of drug efficacy from transcriptional profiles with deep learning
Zhu J, Wang J, Wang X, et al., Zheng R*, Xie Z*
DOI: 10.1038/s41587-021-00946-z ↗Cell Death & Differentiation
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease
Miao Zhao, Bingwei Wang, Chenyu Zhang, et al., Ruimao Zheng*
DOI: 10.1038/s41418-021-00767-2 ↗Redox Biology 47:102134
The Nrf2-NLRP3-Caspase1 axis mediates the neuroprotective effects of Celastrol in Parkinson’s disease
Chenyu Zhang, Miao Zhao, Bingwei Wang, et al., Ruimao Zheng*