团队结合功能形态学、神经科学、分子生物学、遗传编辑、动物模型和组学分析，探索代谢疾病、肥胖、帕金森病等相关疾病的新机制与潜在治疗策略。We integrate functional morphology, neuroscience, molecular biology, genome editing, animal models and omics to investigate mechanisms and therapeutic strategies for metabolic disorders, obesity, Parkinson’s disease and related conditions.
研究中枢神经系统，尤其是下丘脑神经环路对脂肪稳态、能量消耗、脂肪褐变、糖脂代谢和心血管功能的调控机制，重点解析 GABA 能神经元、PKA 信号通路、交感神经投射及神经内分泌因子的作用。We study how central neural circuits, particularly hypothalamic pathways, regulate adipose homeostasis, energy expenditure, adipose browning, glucose and lipid metabolism, and cardiovascular function.
Neural circuits · Metabolism · Functional morphology围绕帕金森病等神经退行性疾病，研究多巴胺神经元功能障碍、神经保护机制、脑内微生态与噬菌体群和疾病发生之间的关系。We investigate Parkinson’s disease and related disorders, including dopaminergic neuron dysfunction, neuroprotection, brain microbiota and phagebiota, and disease-associated molecular pathways.
Dopaminergic neurons · Neuroprotection · Phagebiota探索 CRISPR、单碱基编辑和相关递送体系在遗传病、代谢疾病和神经系统疾病中的应用潜力，推动机制研究与治疗开发衔接。We explore in vivo CRISPR, base editing and delivery systems for genetic, metabolic and neurological diseases, connecting mechanistic research with therapeutic development.
CRISPR · Base editing · Delivery systems研究天然化合物及其衍生物在代谢调控、抗炎和神经保护中的作用，结合细胞、动物模型与组学分析开展药效评估和机制研究。We study natural compounds and derivatives with potential roles in metabolic regulation, anti-inflammatory responses and neuroprotection using cellular assays, animal models and omics.
Natural compounds · Pharmacology · Omics研究跨越神经环路、分子信号、细胞功能及疾病模型，综合运用组织形态学、遗传学、基因编辑、药理学和组学方法。Our work spans neural circuits, molecular signaling, cellular function and disease models, combining morphology, genetics, genome editing, pharmacology and omics.