连接神经环路、
代谢稳态与
疾病转化Neural circuits
Metabolism
Translation
郑瑞茂课题组聚焦代谢与心血管调控的神经和分子机制、神经退行性疾病、基因编辑治疗及药用天然化合物研究We study neural and molecular control of metabolism and cardiovascular function, neurodegeneration, genome editing and medicinal natural compounds
从机制发现到治疗探索From mechanism to therapy
跨越神经环路、细胞功能、分子信号与疾病模型，衔接基础研究与临床转化Linking fundamental discovery with translation across circuits, cells, molecules and disease models
代谢与心血管调控Metabolic & cardiovascular regulation
研究中枢神经系统，尤其是下丘脑神经环路对脂肪稳态、能量消耗、脂肪褐变、糖脂代谢和心血管功能的调控机制，重点解析 GABA 能神经元、PKA 信号通路、交感神经投射及神经内分泌因子的作用We study how central neural circuits, particularly hypothalamic pathways, regulate adipose homeostasis, energy expenditure, adipose browning, glucose and lipid metabolism, and cardiovascular function
02神经退行性疾病Neurodegenerative disease
围绕帕金森病等神经退行性疾病，研究多巴胺神经元功能障碍、神经保护机制、脑内微生态与噬菌体群和疾病发生之间的关系We investigate Parkinson’s disease and related disorders, including dopaminergic neuron dysfunction, neuroprotection, brain microbiota and phagebiota, and disease-associated molecular pathways
03基因编辑与基因治疗Genome editing & gene therapy
探索 CRISPR、单碱基编辑和相关递送体系在遗传病、代谢疾病和神经系统疾病中的应用潜力，推动机制研究与治疗开发衔接We explore in vivo CRISPR, base editing and delivery systems for genetic, metabolic and neurological diseases, connecting mechanistic research with therapeutic development
04药用天然化合物Medicinal natural compounds
研究天然化合物及其衍生物在代谢调控、抗炎和神经保护中的作用，结合细胞、动物模型与组学分析开展药效评估和机制研究We study natural compounds and derivatives with potential roles in metabolic regulation, anti-inflammatory responses and neuroprotection using cellular assays, animal models and omics
新脂肪因子“脂调素”LeptolinAdipocyte-derived factor Leptolin
团队发现新型脂肪因子 Leptolin，并提出其在增强能量消耗、预防肥胖和改善糖脂代谢中的潜在作用The team identified Leptolin and its potential to increase energy expenditure and improve metabolic health